Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1989-02-15
1990-08-14
Shen, Cecilia
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
544360, 544384, 544385, 544392, 544394, 544398, C07D29508, C07D29510, C07D29512
Patent
active
049488929
ABSTRACT:
A sulfonamide compound represented by the following formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are identical or different, and each represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; R.sup.4 represents a hydrogen atom, a lower alkyl group, or a substituted or unsubstituted aralykyl group; R.sup.5 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted aralkyl group; R.sup.6 and R.sup.7 are identical or different and each represents a hydrogen atom, a lower alkyl group or a lower alkoxy group; and n is an integer of 1 to 8,
and an acid addition salt thereof. The compounds of formula (I) provided by this invention have some useful biological activities such as the spasmolytic activity on the vascular smooth muscles and anti-platelet aggregatory activity and are useful as drugs for treating cardiovascular disorders such as angina pectoris, cerebral circulation disorder and thrombosis.
REFERENCES:
patent: 3880644 (1975-04-01), Beck
patent: 4132786 (1979-01-01), Moreau et al.
patent: 4714700 (1987-12-01), Fournier et al.
Beck, Chem. Abst. 83-193109n (1975).
Lilly, Eli, & Co., Chem. Abst. 84-4812y (1976).
Lilly, Eli, and Co., Chem. Abst. 85-105409y (1976).
Descamps et al., Chem. Abst. 88-6709b (1978).
Bilfing, Chem. Abst. 95-61994k (1981).
Hidaka et al., Chem. Abst. 105-78925m (1986).
Sandoz, S. A., Chem. Abst. 107-39820v (1987).
March, Advanced Org. Chem., 3rd Edition, p. 445.
Kyotani Yoshinori
Ohta Tomio
Sato Seiichi
Tanabe Sohei
Uchida Yasumi
Kowa Comp., Ltd.
Shen Cecilia
LandOfFree
Sulfonamid compound useful for treating cardiovascular disorders does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sulfonamid compound useful for treating cardiovascular disorders, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sulfonamid compound useful for treating cardiovascular disorders will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-464022