Sulfoamino derivatives of chondroitin sulfates of dermatan sulfa

Details Sulfoamino derivatives of chondroitin sulfates of dermatan sulfa Sulfoamino derivatives of chondroitin sulfates of dermatan sulfa

1989-05-02

1991-04-16

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 62, 536 175, 536 185, 536 54, 536 553, 536120, 536122, 536124, A61K 3100, C07H 100, C07H 1500, C08B 3700

Patent

active

050082531

ABSTRACT:
Novel derivatives are disclosed as obtained from chondroitin sulfate, dermatan sulfate and hyaluronic acid, having a molar ratio between sulfate groups and carboxylic groups like that of heparin and furthermore characterized by possessing, as the heparin, the sulfoamino group at the carbon atom at the 6 position of hexosamine.
The novel compounds show a very remarkable clearing activity in comparison with the starting mucopolysaccharides, this activity being similar and for some derivatives comparable with that of heparin.
Moreover, differently from what normally happens upon sulfating the sulfomucopolysaccharides, the anticoagulating activity of the novel compounds is negligible or anyhow very reduced.
The compounds of the present invention find use in the therapy of arteriosclerosis.

REFERENCES:
patent: 4774231 (1988-09-01), Petitou et al.
patent: 4818816 (1989-04-01), Petitou et al.
Hydrazinolysis of Heparin Ando Ther Glycosaminoglycans, Patrick N. Shaklee and H. Edward Conrad, Biochem. J., vol. 217, 1984, pp. 187-197.

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