Sulfoalkyl ether-alkyl ether cyclodextrin derivatives

Details Sulfoalkyl ether-alkyl ether cyclodextrin derivatives Sulfoalkyl ether-alkyl ether cyclodextrin derivatives

2006-04-28

2009-12-01

Maier, Leigh C (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S103000

Reexamination Certificate

active

07625878

ABSTRACT:
A sulfoalkyl ether-alkyl ether cyclodextrin (SAE-AE-CD) derivative is provided. The SAE-AE-CD possesses advantages over known SAE-CD and AE-CD derivatives as well as over the parent cyclodextrin by being more water soluble and less membrane disturbing. The SAE-AE-CD includes at least one sulfoalkyl ether group and at least one alkyl ether group even though the degree of substitution for the functional groups can be different. The SAE functional group can be present in molar excess over the AE functional group and vice versa. The total degree of substitution of the cyclodextrin, with respect to both functional groups, can be varied such that a minority or a majority of the hydroxyl moieties of the CD are derivatized. The SAE-AE-CD derivative can be used to solubilize compounds with insufficient water solubility. In some cases, they also stabilize compounds in solution against degradation or to solubilize degradation products formed during degradation. In addition, SAE-AE-CD can also be used for other purposes such as osmotic agents, agents used to mask the taste of problematic drugs. Surprisingly, while AE-CDs are known to be toxic by being membrane disturbing, SAE-AE-CDs are less membrane disturbing and therefore have greater safety.

REFERENCES:
patent: 5019562 (1991-05-01), Folkman et al.
patent: 5183809 (1993-02-01), Weisz et al.
patent: 5241059 (1993-08-01), Yoshinaga
patent: 5594125 (1997-01-01), Seyschab et al.
patent: 5658894 (1997-08-01), Weisz
patent: 5760015 (1998-06-01), Joullie et al.
patent: 5846954 (1998-12-01), Joullie et al.
patent: 6153746 (2000-11-01), Shah et al.
patent: 2002/0128468 (2002-09-01), Buchanan et al.
patent: 0146841 (1984-04-01), None
patent: WO 01/40316 (2001-06-01), None
Szente, L. et al “Highly soluble cyclodextrin derivatives . . . ” Adv. Drug Deliv. Rev. (1999) vol. 36, pp. 17-28.
Ivanyi, R. et al “Permethyl monoamino beta-cyclodextrin . . . ” Chromatographia (2001) vol. 53, pp. 166-172.
Wistuba, D. et al “Enantiomeric separation by capillary electrochromatography . . . ” Electrophoresis (2005) vol. 26, pp. 2019-2026.
Jiczinszky (“Azido function as protecting group . . . ”, Inter. Cyclo. Symp., 10th, Ann Arbor, MI, USA, May 21-24, 2000, 46-52; Wacker Biochem, Corp., Adrian, MI.
Tarver et al. (“2-O-substituted cyclodextrins . . . ”, Bioorg. Med. Chem. (2002), vol. 10, 1819-1827).
Adam et al. (“Cyclodextrin derived host molecules . . . ”, J. Med. Chem. (2002), vol. 45, 1806-1816).
No NPL documents listed.

Affiliated with

Also associated with

Rating

Sulfoalkyl ether-alkyl ether cyclodextrin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sulfoalkyl ether-alkyl ether cyclodextrin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sulfoalkyl ether-alkyl ether cyclodextrin derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4147140