Sulfenic acid-reactive compounds and their methods of synthesis

Details Sulfenic acid-reactive compounds and their methods of synthesis Sulfenic acid-reactive compounds and their methods of synthesis

2007-11-13

2007-11-13

Gakh, Yelena G. (Department: 1743)

Chemistry of hydrocarbon compounds

Alicyclic compound synthesis

Reexamination Certificate

active

11247045

ABSTRACT:
The present invention provides compounds of Formula I:wherein: R1is a label (e.g., a detectable groups; an anti-tumor agent)s; L is present or absent and when present is a linking group; and x represents an integer from 1 to 10; or a pharmaceutically acceptable salt thereof. The compounds are useful for, among other things, identifying cysteine sulfenic acids in proteins and monitoring oxidative damage in proteins and cells.

REFERENCES:
patent: 24 37 983 (1976-02-01), None
Ellis, Holly R. Novel Application of 7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole To Identify Cysteine Sulfenic Acid in the AhpC Component of Alkyl Hydroperoxide Reductase.Biochemistry, 36, 15013-15018 (1997).
Poole, Leslie B. Measurement of Protein Sulfenic Acid Content.Current Protocols in Toxicology17.2.1-17.2.21. John Wiley & Sons, Inc. (2003).
Poole, Leslie B. Identification of Cysteine Sulfenic Acid in AhpC of Alkyl Hydroperoxide Reductase.Methods in Enzymology, vol. 348, p. 122-136 (2002).
Berry et al. “Direct 4-Alkylation of 1,3-cyclohexamediones via Dianionic Species”Synthesis 6:476-480 (1986).
International Search Report and Written Opinion for PCT/US05/36502; date of mailing Mar. 7, 2007.

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