Sulfenamide taxane derivatives

Details Sulfenamide taxane derivatives Sulfenamide taxane derivatives

1997-07-29

1998-10-13

Owens, Amelia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514100, 5142328, 514255, 514320, 514337, 514422, 549218, 549219, 549511, 548525, 546196, 5462817, 544147, 544359, A61K 31335, A61K 3144, A61K 31445, A61K 31495

Patent

active

058212639

ABSTRACT:
This invention provides a novel series of taxane derivatives which are characterized by the C3' nitrogen bearing one or two sulfur substituents. The new derivatives are antitumor agents useful in the treatment of such cancers as ovarian, breast, lung, gastric, colon, head and neck, melanoma and leukemia.

REFERENCES:
patent: 5453520 (1995-09-01), Bombardelli et al.
patent: 5496846 (1996-03-01), Wilson et al.
patent: 5714512 (1998-02-01), Bastart et al.

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