Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-12-09
1998-01-13
Fonda, Kathleen K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 21, A61K 31725, C08B 3710
Patent
active
057079730
ABSTRACT:
The invention relates to new mixtures of sulfated oligosaccharides having the general structure of heparin constitutive oligosaccharides, having an average molecular mass of 6.+-.0.6 kD, a polydispersiveness close to 1 and the capacity of inhibiting the production of thrombin. The invention also relates to their preparation and to pharmaceutical compositions containing them.
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Thrombosis Res., 38, 389-399 (1985), Mestre et al. Comparative Effects of Heparin and Pk 10169, A Low Molecular Weight Fraction, in a Canine Model of Arterial Thombosis, Month not available.
Thromb. Haemostasis, 63(3), 488-492 (1990), Kovensky et al., Low Anticoagulant Activity of High Sulphated Heparan Sulphates, month not available.
Baron Jean-Pierre
Brun Andre
Hemker Hendrik
Uzan Andre
Darkes Paul R.
Fonda Kathleen K.
Martin Michael B.
Parker III Raymond S.
Rhone-Poulenc Rorer S.A.
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