Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1992-12-28
1995-01-10
Rollins, John W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 54, 536 172, 536 175, 536 176, 536 187, 536 21, A61K 31725, C08B 3710
Patent
active
053807162
ABSTRACT:
Highly sulfated oligosaccharides in the form of hexasaccharide and octasaccharide compounds which have antiproliferative activity with respect to smooth muscle cells are useful in treatment of conditions characterized by unwanted smooth muscle cell proliferation such as a result of trauma or disease states such as asthma, congestive heart failure and hypertension. The oligosaccharides have increased ability to inhibit the proliferation of smooth muscle cells and decreased ability to act as an anticoagulant as compared with commercial heparin and/or unseparated fragments of heparin.
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Brandley Brian K.
Conrad H. Edward
Fugedi Peter
Laine Roger A.
Lam Lun H.
Fonda Kathleen Kahler
Glycomed, Inc.
Rollins John W.
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