Sulfated polysaccharide, pharmaceutically acceptable salt thereo

Details Sulfated polysaccharide, pharmaceutically acceptable salt thereo Sulfated polysaccharide, pharmaceutically acceptable salt thereo

1994-05-12

1996-05-21

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 172, 536 175, 536 54, 536118, 536123, 536124, A61K 31715, C08B 3700, C07H 100

Patent

active

055190103

ABSTRACT:
The present invention provides a sulfated polysaccharide (D-HG), a pharmaceutically acceptable salt thereof, a process for preparing the same and a medicament containing the same as the effective component for DIC (disseminated intravascular coagulation) and thrombosis, the sulfated polysaccharide (D-HG) being prepared by depolymerization of FGAG (a sulfated polysaccharide extracted from a body wall of a sea cucumber with such activities as those of heparin) or a salt thereof and having the following physicochemical properties:

REFERENCES:
patent: 4629699 (1986-12-01), Bianchini
patent: 5063210 (1991-11-01), Lange, III et al.
The Journal Of biological Chemistry, vol. 263, No. 34, 5th Dec. 1988, pp. 18176-18183, The American Society for Biochemistry and Molecular Biology, Inc., U.S.; R. P. Vieira et al.
English Language Abstract of Japanese Document No. 61-22021 (A), Jan. 30, 1986.
English Language Abstract of Japanese Document No. 63-126981 (A), May 30, 1988.
1-Pharmacology, vol. 109, issued 1988, Zhang et al, "Anticoagulant effect of Holothuria leucospilota acid mucopolysaccharide", see p. 45, col. 2, the abstract No. 31852c, Zhongguo Yaolixue Yu Dulixue Zazhi 1988, 2(2), 98-101 (Ch).
1-Pharmacology, vol. 107, issued 1987, Shan et al, "Effects of an acid Polysaccharide from Holothuria leucospilota on the platelet aggregation in rabbits" see p. 45, col. 1, the abstract No. 190638n, Zhongguo Yaoli Xuebao 1987, 8 (5), 447-50 (Ch).
Chemical Abstracts, vol. 99, issued 1983, Fan et al, "Acidic Polysaccharides from Holothuria leucospilota (Brandt)", see p. 394, col. 2, the abstract No. 19901k, Yaoxue Xuebao 1983, 18(3), 203-8 (Ch).
63-Pharmaceutical, vol. 94, issued 1981, Fan et al, "Isolation of an acidic mucopolysaccharide from Stichopus japonicus selenka and some of its physical and chemical properties", see p. 357, col. 2, the abstract No. 52763m, Yao Hsueh Hsueh Pao 1980, 15(5), 263-70 (Ch).

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