Sulfated nonionic block copolymer surfactants as stabilizer coat

Details Sulfated nonionic block copolymer surfactants as stabilizer coat Sulfated nonionic block copolymer surfactants as stabilizer coat

1995-01-24

1996-10-29

Mullis, Jeffrey C.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

X-ray contrast imaging agent

424489, 424490, 42421336, A61K 914

Patent

active

055694489

ABSTRACT:
This invention provides a composition comprised of nanoparticles containing a therapeutic or diagnostic agent having a block copolymer linked to at least one anionic group as a surface modifier adsorbed on the surface thereof and a method of making such nanoparticles. The compositions exhibit unexpectedly improved autoclave stability, reduced macrophage uptake, improved toxicological profiles and facilitate particle size reduction such that milling time can be reduced and/or sterile filtration of the nanoparticles can be accomplished.

REFERENCES:
patent: 4304691 (1981-12-01), Farmer, III et al.
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5318767 (1994-06-01), Liversidge et al.
patent: 5340564 (1994-08-01), Illig et al.

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