Sulfated glycosaminoglycanoid derivatives of the dermatan sulfat

Details Sulfated glycosaminoglycanoid derivatives of the dermatan sulfat Sulfated glycosaminoglycanoid derivatives of the dermatan sulfat

1992-07-27

1995-01-17

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 54, 514 61, 536118, 536120, 536121, A61K 3170, A61K 31715, C07H 1312, C07H 2300

Patent

active

053825705

ABSTRACT:
The invention relates to sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type, of which N-sulfate, N-acetate, and hydroxy groups, are replaced by alkoxy, aryloxy, aralkoxy, or O-sulfate groups. The compounds have antithrombotic and smooth muscle cell proliferation inhibiting activities.

REFERENCES:
patent: 3301848 (1967-01-01), Halleck
patent: 4105760 (1978-08-01), Szejtli et al.
patent: 4221907 (1980-09-01), Nair et al.
patent: 4818816 (1989-04-01), Petitou et al.
patent: 4841041 (1989-06-01), van Boeckel et al.
Cancer Research, vol. 49, issued Aug. 1, 1989, Tietze et al, "Proton-Mediated Liberation of Aldophamide from a Nontoxic Prodrug: A Strategy for Tumor-Selective Activation of Cytocidal Drugs", pp. 4179-4184.

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