Sulfated glycosaminoglycanoid derivatives of the dermatan sulfat

Details Sulfated glycosaminoglycanoid derivatives of the dermatan sulfat Sulfated glycosaminoglycanoid derivatives of the dermatan sulfat

1996-05-23

1997-09-16

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536118, 536120, 5361231, C07H 100, C07H 1312

Patent

active

056682743

ABSTRACT:
The invention relates to sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type, of which N-sulfate, N-acetate, and hydroxy groups, are replaced by alkoxy, aryloxy, aralkoxy, or O-sulfate groups. The compounds have antithrombotic and smooth muscle cell proliferation inhibiting activities.

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L.F. Tietze et al., "Proton-mediated Liberation of Aldophosphamide from a Nontoxic Prodrug: A Strategy for Tumor-selective Activation of Cytocidal Drugs," Cancer Research, vol. 49, pp. 4179-4184, Aug. 1, 1989.

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