Sulfated glycolipids and antibodies thereto for prophylaxis or t

Details Sulfated glycolipids and antibodies thereto for prophylaxis or t Sulfated glycolipids and antibodies thereto for prophylaxis or t

1995-02-28

1998-10-27

Fonda, Kathleen K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 53, 514 54, 514866, 5303872, 5303875, 5303881, 5303891, 536 176, A61K 3170, C07K 1600, C07H 1500

Patent

active

058278281

ABSTRACT:
Methods for the treatment of prediabetes or diabetes in an individual comprise administering to the individual a therapeutically active agent comprising a glycolipid having a galactose-3-O-sulfate moiety capable of binding to islet cell antibodies. Methods of detecting or quantifying islet cell antibodies in a sample, methods for the detection of Langerhans islet cells, methods for monitoring the development of prediabetes, diabetes or symptoms thereof in an individual and methods for prophylactic treatment against the development of prediabetes or diabetes also involve the use of a glycolipid having a galactose-3-O-sulfate moiety.

REFERENCES:
patent: 5288706 (1994-02-01), Yamanouchi et al.
Berkow et al., eds., "The Merck Manual" sixteenth edition, Merck Research Laboratories (Rahway, NJ) 1992, pp. 955-970.
Goodman et al., eds., "Goodman and Gilman's The Pharmaceutical Basis of Therapeutics", Pergamon Press, Inc. (Elmsford, NY) 1990, pp. 1471-1475.
Zubay "Biochemistry", The Benjamin/Cummings Publishing Company, Inc. (Menlo Park, CA) 1983, pp. 20-22.
Stevenson et al., Chem. Abs. No. 78882x, STN International, vol. 116, No. 9 (1992).
Fredman et al. Biochem. J. 1988, 251, 17-22.

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