Sulfated glyceroglucolipids as inhibitors of bacterial adherence

Details Sulfated glyceroglucolipids as inhibitors of bacterial adherence Sulfated glyceroglucolipids as inhibitors of bacterial adherence

1990-11-20

1992-05-26

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 53, 514 54, 514 61, A01N 4304

Patent

active

051168219

ABSTRACT:
The subject invention involves pharmaceutical compositions comprising a sulfated glyceroglucolipid having the structure: ##STR1## wherein n is an integer of from 1 to about 5, R is hydrogen or C.sub.1 -C.sub.24 acyl or alkyl, R' is hydrogen or C.sub.1 -C.sub.24 acyl or alkyl, and M.sup.+ is a cationic moiety, and methods of treating or preventing gastroduodenal diseases or disorders caused by or associated with H. pylori by administering such compounds.

REFERENCES:
patent: 4464360 (1984-08-01), Leffler
patent: 4912093 (1990-03-01), Michaeli
Slomiany et al "Sufation of Glycolipids." Digestion 36:246-252 (1987).
Gigg, R., "The Allyl Ether as a Protecting Group in Carbohydrate Chemistry Part 10. Synthesis of 3-0-(.beta.-D-Galactopyranosyl 3-sylphate)-2-O-hexadecanoyl-1-O-hexadecyl-L-glycerol, `Seminolipid`", Journal of the Chemical Society, Perkin Transactions 1, No. 3 (1979), pp. 712-718.
Gigg, R., "Studies on the Synthesis of Sulfur-Containing Glycolipids (Sulfoglycolipids)", Carbohydrate Sulfates, American Chemical Society Symposium Series, vol. 77 (1978), pp. 44-66.
Slomiany, B. L., J. Piotrowski, A. Samanta, K. VanHorn, V. L. N. Murty & A. Slomiany, "Campylobacter pyrlori Colonization Factor Shows Specificity for Lactosylceramide Sulfte and GM3 Ganglioside", Biochemistry International, vol. 19, No. 4, (Oct. 1989), pp. 929-936.
Lingwood, C. A., H. Law, A. Pellizzari, P. Sherman & B. Drumm, "Gastric Glycerolipid as a Receptor for Camplobacter pylori", The Lancett, Jul. 29, 1989, pp. 238-241.

Affiliated with

Also associated with

Rating

Sulfated glyceroglucolipids as inhibitors of bacterial adherence does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sulfated glyceroglucolipids as inhibitors of bacterial adherence, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sulfated glyceroglucolipids as inhibitors of bacterial adherence will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-419759