Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-07-22
2008-07-22
Davis, Zinna N (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S139000, C546S146000
Reexamination Certificate
active
10556906
ABSTRACT:
Sulfated bis-cyclic compounds that are potent anticoagulants and methods for their manufacture are provided. The sulfated compounds are bis-cyclic moieties comprised of an isoquinoline ring joined to a phenyl ring with the general chemical structure formula (I) where R2is hydrogen or a sulfate moiety, R3is either hydrogen or carboxylate moiety; R4is a hydrogen or oxygen; and R5is a hydrogen if R4is a hydrogen, and is absent if R4is oxygen. Counterions such as sodium may also be coordinated to the sulfate and carboxylate moieties.
REFERENCES:
patent: 5578729 (1996-11-01), Bringmann et al.
patent: 6849644 (2005-02-01), Bromidge et al.
Gunnarsson et al., “Designing Small, Nonsugar Activators of Antithrombin Using Hydrophathic Interaction Analyses”, J. Med. Chem, 2000 vol. 45, pp. 1233-1243.
Gannarsson et al., Interaction of designed Sulfated Falvanoids with Antithrombin: Lessons on the Design of Organic Activators; J. Med. Chem,; 2002, vol. 45, pp. 4460-4470.
Desai Umesh R.
Gunnarsson Gunnar
Davis Zinna N
Virginia Commonwealth University
Whitham Curtis Christofferson & Cook PC
LandOfFree
Sulfated bis-cyclic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sulfated bis-cyclic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sulfated bis-cyclic agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3918254