Sulfate transferase and DNA encoding this enzyme

Details Sulfate transferase and DNA encoding this enzyme Sulfate transferase and DNA encoding this enzyme

2006-12-19

2006-12-19

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S183000, C435S006120, C435S069100, C435S320100

Reexamination Certificate

active

07150981

ABSTRACT:
A glycosaminoglycan 6-O-sulfotransferase having an activity of transferring sulfate to a hydroxyl at position 6 of a glycosamine residue of a glycosaminoglycan, which has a ratio of relative activities to substrates satisfying completely desulfated N-acetylated (CDSNAc) heparin/completely desulfated N-resulfated (CDSNS) heparin≧0.05 and a molecular weight as calculated from constituent amino acids of from 53,000 to 58,000 daltons.

REFERENCES:
patent: 967272 (1999-12-01), None
patent: 11-69983 (1999-03-01), None
patent: 2002-60566 (2002-02-01), None
patent: WO 01/90334 (2001-11-01), None
patent: WO 02/12467 (2002-02-01), None
Habuchi et al., EMBL Database Accession No. Q9QYK6, “Heparan sulfate 6-sulfotransferase 2”, created May 1, 2000.
Habuchi, H, et al., The Occurrence of Three Isoforms of Heparan Sulfate 6-O-Sulfotransferase Having Different Specificities for Hexuronic Acid Adjacent to the Targeted N-Sulfoglucosamine, J. Biol. Chem., Jan. 2000, vol. 275, pp. 2859-2868.
Supplementary Partial European Search Report completed on Mar. 24, 2004 and issued to a pending related application.
Supplementary European Search Report completed on Jul. 6, 2004 and issued to a related foreign application.

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