Sulfamide-metalloprotease inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514255, 514300, 514301, 514302, 514318, 514330, 514331, 514562, 544350, 544360, 544380, 546113, 546114, 546115, 546193, 546225, 546235, 562556, A61K 31435, A61K 31495, C07D491048, C07D49504

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active

059984120

ABSTRACT:
This invention relates to sulfamides of formula (I) ##STR1## that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

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von Geldern, et al., Journal of Medicinal Chemistry, vol. 39:4, (1996), pp. 968-981, "Azole Endothelin Antagonists".
Chatterjee, et al., Bioorganic & Medicinal Chemistry Letters, vol. 6:11, 1996, pp. 1237-1240, "Potent Fluoromethyl Ketone Inhibitors of Recombinant Human Calpain l+".
Patt, et al., J. Med. Chem., vol. 35:14, 1992, pp. 2562-2572, "Structure-Activity Relationships of a Series of 2-Amino-4-thiazole-Containing Renin Inhibitors".

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