Sulfamate compound containing carbamoyl group

Details Sulfamate compound containing carbamoyl group Sulfamate compound containing carbamoyl group

1996-03-14

1997-08-05

O'Sullivan, Peter

Organic compounds -- part of the class 532-570 series

Organic compounds

Sulfonate esters

C07C30963, A61K 3127, A61K 31255

Patent

active

056544618

ABSTRACT:
3-O-Carbamoyl-2-phenyl-1,3-propanediol sulfamate racemate, represented by the following structural formula I: ##STR1## and its (R)- and (S)-optical isomers, which are very effective for prophylaxis and the treatment of central nervous system disorders including nervous muscular pain, epilepsy and minimal brain dysfunctions, are disclosed. They are prepared from 2-phenyl-1,3-propanediol monocarbamate and its optical isomers, respectively.

REFERENCES:
patent: 4792569 (1988-12-01), Maryanoff et al.
patent: 5384327 (1995-01-01), Costanzo et al.
patent: 5510379 (1996-04-01), Lee et al.
Maryanoff et al., "Anticonvulsant O-Alkyl Sulfamates, etc.", J. Med. Chem., 30, 880-887. 1987.

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