Suksdorfin analogs, compositions thereof, and methods for making

Details Suksdorfin analogs, compositions thereof, and methods for making Suksdorfin analogs, compositions thereof, and methods for making

1995-06-05

1998-03-10

Trinh, Ba K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514460, 549280, 549282, A61K 31365, C07D31194, C07D49306

Patent

active

057262047

ABSTRACT:
The present invention is directed to compounds that are analogs of the natural product suksdorfin. Compounds of the present invention include those having Formula I: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined herein. The invention is also directed to methods of making these compounds, pharmaceutical compositions including these compounds and methods of using the compounds to inhibit retroviral infections in cells and tissues of animals. A method for stereoselectively preparing compounds within the scope of the invention by catalytic asymmetric dihydroxylation is also disclosed.

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