Sugar-substituted 2-azetidinones useful as hypocholesterolemic a

Details Sugar-substituted 2-azetidinones useful as hypocholesterolemic a Sugar-substituted 2-azetidinones useful as hypocholesterolemic a

1996-10-29

1998-05-26

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 174, 536 181, A61K 3170, C07H 1500

Patent

active

057564701

ABSTRACT:
Hypocholesterolemic sugar-substituted 2-azetidinones are disclosed, as well as a method of lowering cholesterol by administering said compounds, pharmaceutical compositions containing them, and the combination of a sugar-substituted 2-azetidinone cholesterol-lowering agent and a cholesterol biosynthesis inhibitor for the treatment and prevention of atherosclerosis.

REFERENCES:
patent: 4602003 (1986-07-01), Malinow
patent: 4602005 (1986-07-01), Malinow
Witzum, Circulation, 80, 5 (1989), pp. 1101-1114.
Illingworth, Drugs, 36(Supp. 3) (1988), pp. 63-71.
Atherosclerosis, 115 (1995), pp. 45-63.
Sybertz et al, "SCH 48461, a novel inhibitor of cholesterol absorption," Athersclerosis X, ed. Woodford et al (Elsevier Science B.V., 1995), pp. 311-315.

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