Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-05-22
2007-05-22
Brusca, John S. (Department: 1631)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
Reexamination Certificate
active
08486066
ABSTRACT:
The present invention provides a nucleotide having the formula,wherein PM is a phosphate moiety, SM is a ribose or a deoxyribose sugar moiety, and BASE is a pyrimidine, purine or 7-deazapurine moiety. PM is attached to SM at a position independently selected from the 2′, 3′, and 5′ positions of SM when the nucleotide is a ribonucleotide, and at a position independently selected from the 3′ and 5′ positions when the nucleotide is a deoxyribonucleotide. BASE is attached to the 1′ position of SM from the N1position when BASE is a pyrimidine, or the N9position when BASE is a purine or 7-deazapurine. Sig is a detectable moiety covalently attached to SM directly or through a linkage group. Also provided are an oligo- or polynucleotide comprising at least one such sugar moiety labeled nucleotide, and other compositions including those wherein a polypeptide is terminal ligated or attached to the oligo- or polynucleotide. The sugar moiety labeled nucleotide, and the oligo- or polynucleotides and other compositions comprising such nucleotides, are useful as diagnostic tools for detecting analytes and as therapeutic agents.
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Engelhardt Dean
Kirtikar Dollie
Kline Stanley
Rabbani Elazar
Stavrianopoulos Jannis G.
Brusca John S.
Enzo Life Sciences, Inc. c/o Enzo Biochem, Inc.
Fedus Ronald C.
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