Sugar modified interferon

Drug – bio-affecting and body treating compositions – Lymphokine – Interferon

Patent

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Details

514 2, 514 12, 514 21, 530351, 530402, A61K 3821, G07K 1710

Patent

active

057231214

ABSTRACT:
Sugar-modified interferon, modified with at least one galactose residue, which is a binding reaction product between lactose lactone and interferon is disclosed. The sugar-modified interferon, which can be obtained through simple chemical manipulation on IFN, has improved accumulating properties in the liver and enhanced physiological activities as compared with unmodified IFN.

REFERENCES:
patent: 4377567 (1983-03-01), Geho
patent: 5037969 (1991-08-01), Minami et al.
Chemical Abstract: 121; 177704a, 1989.
Chemical Abstract: 111; 201591c, 1994.
J. Biol. Chem., 251, 1296-1302 (1976).
J. Biol. Chem., 258, 199-202 (1983).

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