Sugar-coated solid dosage forms

Details Sugar-coated solid dosage forms Sugar-coated solid dosage forms

1977-06-06

1979-11-27

Silverberg, Sam

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

427 3, A61K 936

Patent

active

041761758

ABSTRACT:
The sugar-coated solid dosage forms have improved disintegrability even in a neutral medium after prolonged storage, with sugar-coating layers having excellent mechanical strengths. The coating layer that is in direct contact with the surface of the solid dosage form contains a water-insoluble hydroxypropyl cellulose with a relatively low content of hydroxypropoxy groups, say, from 4 to 16% by weight. The hydroxypropyl cellulose is used by being suspended in the coating syrup or mixed in the dusting powder for purposes of subcoating. It is also possible to use the hydroxypropyl cellulose in the form of suspension to form a smoothing coat.

REFERENCES:
patent: 2816062 (1957-12-01), Doerr
patent: 3679794 (1972-07-01), Bentholm
patent: 3852421 (1974-12-01), Koyanagi
patent: 4001390 (1977-01-01), Ohno

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