Sugar chain-containing albumin, production method thereof...

Details Sugar chain-containing albumin, production method thereof... Sugar chain-containing albumin, production method thereof...

2011-05-17

2011-05-17

Carlson, Karen Cochrane (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000

Reexamination Certificate

active

07943570

ABSTRACT:
Glycosylated albumin as a drug carrier for a DDS targeting the liver (particularly kupffer's cell) can be provided by mutating a DNA encoding albumin to encode a mutant albumin containing a partial amino acid sequence permitting glycosylation modification by eukaryotic cell, preferably a consensus sequence of N-linked sugar chain, introducing an expression vector containing the mutant DNA into a host eukaryotic cell, preferably a host cell permitting addition of a high-mannose type sugar chain, culturing the obtained transformant, and recovering a glycosylated albumin protein from the obtained culture.

REFERENCES:
patent: 2008-43285 (2008-02-01), None
Taguchi et al. 1999; Inhibition of advanced protein glycation by Schiff base between aminoguanidine and pyridoxyl. Eur. J. Pharm. 378(3): 283-289.
Candiano et al. 1984; Glycosylation of human albumin in diabetes mellitus: Extensive microheterogeneity of serum and urinary species as revealed by isoelectric focusing. Electrophoresis 5: 217-222.
Yang et al. 1994; Advanced glycation end products up-regulate gene expression found in diabetic glomerular disease. PNAS 91(20): 9436-9440.
www.macromolecularinsights/albumin.php (2009).
Makita et al. 1992; Immunodetection of advanced glycosylation end-products in vivo. Journal Biol. Chem. 267: 5133-5138.
Bause 1983; Structural requirements of N-glycosylation of proteins. Biochem J. 209:331-336.
Higuchi et al.,International Journal of Pharmaceutics, 287: 147-154 (2004).
Lee et al.,Biochemistry, 15(18): 3956-3963 (Sep. 7, 1976) (Abstract).
Nishikawa et al.,Am. J. Physiol. Gastrointest. Liver Physiol, 268: G849-G856 (1995).
Opanasopit et al.,Am. J. Physiol. Gastrointest. Liver Physiol., 280: 879-889 (2001).
Takakura et al.,Biochemical Pharmacology, 47(5): 853-858 (1994).
Yamasaki et al.,The Journal of Pharmacology and Experimental Therapeutics, 301(2): 467-477 (2002).
Brennan et al.,Proc. Natl. Acad. Sci. USA, 87: 26-30 (Jan. 1990).
Melgert et al.,Hepatology, 34(4): 719-728 (2001).
Peach et al.,Biochimica et Biophysica Acta., 1097: 49-54 (1991).
Sakamoto et al.Biochim. Biophys. Acta., 1252: 209-216 (1995).
Meyers, Robert A., ed., “Glycoproteins, Secretory” inMolecular Biology and Biotechnology: A Comprehensive Desk Reference(VCH Publishers, Inc., New York, 1995), p. 390.

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