Sucrose alkyl 4,6-orthoacylates

Details Sucrose alkyl 4,6-orthoacylates Sucrose alkyl 4,6-orthoacylates

1989-03-13

1989-12-26

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536115, 536119, 536124, C07H 1304, C07H 1520, C07D30720, C07D30912

Patent

active

048899283

ABSTRACT:
Sucrose 6-acylates, key intermediates in the preparation of sucralose, can be prepared by subjecting a sucrose alkyl 4,6-orthoacylate to mild aqueous acidic hydrolysis to provide a mixture of sucrose 4- and 6-acylates and then treating the mixture with a base to convert the 4- acylate to the 6-acylate.
The novel sucrose alkyl 4,6-orthoacylates are prepared by reacting sucrose in solution or suspension in an inert organic solvent with a trialkyl orthoacrylate in the presence of an acid catalyst.

REFERENCES:
patent: 4362869 (1982-12-01), Jenner et al.
patent: 4380476 (1983-04-01), Mufti et al.
patent: 4405654 (1983-09-01), Lee

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