Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1988-01-27
1990-06-05
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530350, 530402, 530403, 530404, 530405, 530406, 530408, 530409, 530410, 6048901, 6048911, 514 2, 514 8, 514 12, 514 21, 424422, 424443, 424464, 424 851, 424 852, C07K 1300, C07K 1700, A61K 952
Patent
active
049315447
ABSTRACT:
A pharmaceutical composition is prepared wherein biologically active conjugated interleukin-2 is dissolved in an aqueous carrier medium without the presence of a solubilizing agent. The unconjugated IL-2, which is not water soluble or not readily soluble in water at pH 6-8 without such solubilizing agent, is selectively conjugated to one or more succinyl groups by reaction with succinic anhydride.
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Katre Nandini
Knauf Michael J.
Cetus Corporation
Draper Garnette D.
Halluin Albert P.
Hasak Janet E.
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