Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1993-08-24
1995-10-31
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
562426, 562556, 564 74, 564 88, 564 89, 564101, 560 13, C07C30702, C07C32702
Patent
active
054631041
ABSTRACT:
Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
REFERENCES:
patent: H725 (1990-01-01), Gordon
patent: 4450164 (1984-05-01), Bristol et al.
patent: 4477441 (1984-10-01), Boger et al.
patent: 4514391 (1985-04-01), Gordon et al.
patent: 4548926 (1985-10-01), Matsueda et al.
patent: 4599198 (1986-07-01), Hoover
patent: 4616088 (1986-10-01), Ryono et al.
patent: 4629724 (1986-12-01), Ryono et al.
patent: 4668769 (1987-05-01), Hoover
patent: 4668770 (1987-05-01), Boger et al.
patent: 4757050 (1988-07-01), Natarajan et al.
patent: 4880938 (1989-11-01), Freidinger
patent: 4963530 (1990-10-01), Hemmi et al.
patent: 4977277 (1990-12-01), Rosenberg et al.
Roberts et al, "Rational Design of Peptide-based Proteinase Inhibitors," Science, 248, 358 (1990).
Erickson et al, "Design Activity, and 2.8.ANG.Crystal Structure of a C.sub.2 Symmetric Inhibitor Complexed to HIV-1 Protease," Science, 249, 527 (1990).
Pearl et al, "Sequence specificity of retroviral proteases" Nature, 328, (1987).
Martin, Drugs of the Future, 16(3), 210-212 (1991).
Meek et al, Letter To Nature, 343, 90-92 (1990).
McQuade et al, Science, 247, 454-456 (1990).
Rich et al, Peptide Inhibitors of Proteases, 511-520 (1983).
Rosenberg et al, J. Med. Chem., 30, 1224-1228 (1987).
DeCrescenzo Gary A.
Freskos John N.
Getman Daniel
Mueller Richard A.
Talley John J.
Conrad, III Joseph M.
Dees Jos,e G.
G. D. Searle & Co.
Ungemach Frank s.
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