Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Patent
1998-03-12
2000-02-08
Gerstl, Robert
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
544159, 546336, 549 65, 560 13, 562430, 564 90, C07C30702, C07C32702
Patent
active
060229942
ABSTRACT:
Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
REFERENCES:
patent: H725 (1990-01-01), Gordon
patent: 4450164 (1984-05-01), Bristol et al.
patent: 4477441 (1984-10-01), Boger et al.
patent: 4514391 (1985-04-01), Gordon et al.
patent: 4548926 (1985-10-01), Matsueda et al.
patent: 4599198 (1986-07-01), Hoover
patent: 4616088 (1986-10-01), Ryono et al.
patent: 4668769 (1987-05-01), Hoover
patent: 4668770 (1987-05-01), Boger et al.
patent: 4757050 (1988-07-01), Natarajan et al.
patent: 4880938 (1989-11-01), Freidinger
patent: 4963530 (1990-10-01), Hemmi et al.
patent: 4977277 (1990-12-01), Rosenberg et al.
Roberts et al, "Rational Design of Peptide-based Proteinase Inhibitors," Science, 248, 358 (1990).
Erickson et al, "Design Activity, and 2.8.ANG. Crystal Structure of a C.sub.2 Symmetric Inhibitor Complexed to HIV-1 Protease," Science, 249, 527 (1990).
Pearl et al, "Sequence specificity of retroviral proteases" Nature, 328, (1987).
Martin, Drugs of the Future, 16(3), 210-212 (1991).
Meek et al, Letter To Nature, 343, 90-92 (1990).
Rosenberg et al, J. Med. Chem., 30, 1224-1228 (1987).
DeCrescenzo Gary A.
Freskos John N.
Getman Daniel
Mueller Richard A.
Talley John J.
G. D. Searle &. CO.
Gerstl Robert
LandOfFree
Succinoylamino hydroxyethylamino sulfonamides useful as retrovir does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Succinoylamino hydroxyethylamino sulfonamides useful as retrovir, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Succinoylamino hydroxyethylamino sulfonamides useful as retrovir will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1682423