Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-08-19
1993-10-26
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514212, 5142275, 5142278, 5142352, 5142358, 5142355, 5142372, 5142315, 5142378, 514252, 514253, 514255, 514318, 514315, 514343, 514357, 514397, 514400, 514414, 514419, 514422, 514424, 514438, 514319, 514326, 514428, 514562, 514616, 540597, 540602, 540603, 540596, 540610, 544 581, 544 585, 544 586, 544 587, 544 59, 544 60, 544 62, 544131, 544139, 544143, 544145, 544159, 544160, 544360, 544370, 544373, 544379, 544400, 546192, 546193, 546194, 546201, 546208, 546212, 546213, 546247, 546281, 546335, 548336, 5483
Patent
active
052566579
ABSTRACT:
Compounds having the structural formula ##STR1## wherein X is HONH or HO and especially wherein the carbon atom bearing CH.sub.2 R.sup.1 has the R-configuration, the carbon atom bearing CH.sub.2 R.sup.2 has the S-configuration, R.sup.1 is isopropyl, R.sup.2 is 3-indolyl, m is 2, n is 0, p is 2 and R.sup.3 and R.sup.4 taken alone are each methyl or R.sup.3 and R.sup.4 taken together with N are morpholino and pharmaceutically acceptable acid addition salts or solvates or acid addition salts-solvates thereof, which are matrix-metalloprotease inhibitors useful in treatment of disease in which matrix-metalloprotease promoted connective tissue remodelling is a causative factor, for example, rheumatoid arthritis and cancer, and a method of preparation and method of use thereof and methods of preparation of intermediates therefor are disclosed.
Gainor James A.
Gordon Thomas D.
Morgan Barry A.
Singh Jasbir
Wahl Robert C.
Hohenschutz Liza D.
Richter Johann
Sterling Winthrop Inc.
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