Subunit vaccine against Neisseria meningitidis infections and co

Details Subunit vaccine against Neisseria meningitidis infections and co Subunit vaccine against Neisseria meningitidis infections and co

1995-05-25

1999-07-27

Housel, James C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

4242491, 530350, A61K 39095

Patent

active

059286504

ABSTRACT:
The present invention relates to the lower molecular weight subunit of the human transferrin receptor of a strain of N. meningitidis, in purified form, as well as to a vaccinal pharmaceutical composition intended for the prevention or attenuation of the effects of an N. meningitidis infection, containing the said subunit in purified form.

REFERENCES:
patent: 5141743 (1992-08-01), Schryvers
Black, J.R. et al. (1986) Human immune response to iron-repressible outer membrane proteins of Neisseria meningitidis. Infect. Immun. 54:710-713.
Dyer, D.W. et al. (1985) The relationship between iron utilzation and virulence of the pathogenic Neisseria. pp. 177-191. Bayer Symposium VIII. The Pathogenesis of Bacterial Infections. Springer-Verlag KG, Berlin.
Nirupama Banerjee-Bhatnagar et al, "Expression of Neisseria meningitidis Iron-Regulated Outer Membrane Proteins, Including a 70-Kilodalton Transferrin Receptor, and Their Potential for Use as Vaccines," Infection and Immunity, vol. 58, No. 9, 1990, pp. 2875-2881.
Anthony B. Schryvers et al, "Identification and Characterization of the Human Lactoferrin-Binding Protein from Neisseria meningitidis," Infection and Immunity, vol. 56, No. 5, 1988, pp. 1144-1149.
Anthony B. Schryvers et al, "Identification and Characterization of the Transferrin Receptor from Neisseria meningitidis," Molecular Microbiology, (1988) vol. 2, No. 2, pp. 281-288.
Saukkonen et al., "Comparative Evaluation of Potential Components for Group .beta. Meningococcal Vaccine by Passive Protection in the Infant Rat and in vitro Bactericidal Assay", Vaccine, vol. 7, Aug. 1989, pp. 325-329.
Zollinger et al., "Importance of Complement Source in Bactericidal Activity of Human Antibody and Murine Monoclonal Antibody to Meningococcal Group B Polysaccharide", Infection and Immunity, vol. 40, No. 1, 1983, pp. 257-264.
Zollinger et al., "Meningococcal Vaccines--Present and Future", Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 85, Suppl. 1, 1991, pp. 37-43.
Pettersson et al., "Monoclonal Antibodies Against the 70-Kiladalton Iron-Regulated Protein of Neisseria meningitidis are Bactericidal and Strain Specific", Infection and Immunity, Sep. 1990, pp. 3036-3041.
Geysen et al., "Cognitive Features of Continuous Antigenic Determinants", Journal of Molecular Recognition, vol. 1, No. 1, 1988, pp. 32-41.

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