Substrates with topographical features for the manipulation...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism

Reexamination Certificate

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Reexamination Certificate

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10480780

ABSTRACT:
The present invention relates to novel substrates, to methods of making them and to uses therefor. The substrates of the invention comprise a base portion and a surface layer covering at least part of the base portion, with a binding layer provided therebetween. The surface layer provides, on at least a part of the substrate, topographical features having at least one nano scale dimension. These topographical features are adapted to facilitate, influence, control or inhibit cell or tissue growth thereon and/or therebetween and the substrate may be used for the study, manipulation or modification of at least one cellular or tissue behavior or response.

REFERENCES:
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patent: WO 00/66036 (2000-11-01), None
Flemming R. G. et al. Effects of Synthetic Micro and Nano Structured Surfaces on Cell Behavior. Biomaterials vol. 20, paes 573-588, 1999.
E.T. den Braber et al. (1996) “Quantitative analysis of cell proliferation and orientation on substrata with uniform parallel surface micro-grooves”Biomaterialsvol. 17 No. 11 pp. 1093-1099, Elsevier Science Limited.
Goodman et al. (1996) “Three-dimensional extracellular matrix textured biomaterials”Biomaterialsvol. 17, No. 21, pp. 2087-2095 (Elsevier Science Limited).
Wojciak-Stothard et al. (1996) “Guidance and Activation of Murine Macrophages by Nanometric Scale Topography”Experimental Cell Researchvol. 223, pp. 426-435, Article No. 0098, Academic Press, Inc.
Oakley et al. (1997) “Sensitivity of Fibroblasts and Their Cytoskeletons to Substratum Topographies: Topographic Guidance and Topographic Compensation by Micromachined Grooves of Different Dimensions”Experimental Cell Researchvol. 234 pp. 413-424 Article No. EX973625, Academic Press, Inc.
Flemming et al. (1999) “Effects of synthetic micro- and nano-structured surfaces on cell behavior”Biomaterialsvol. 20 pp. 573-588, Elsevier Science Ltd.

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