Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Reexamination Certificate
2003-10-28
2009-10-27
Desai, Anand U (Department: 1656)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
C514S002600, C435S041000
Reexamination Certificate
active
07608682
ABSTRACT:
The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel substrates, enzymes and modulators of N-end rule ubiquitylation. The present invention also relates to specific substrates of N-end rule ubiquitylation as well as activated fragments of these substrates, proteases that expose N-degrons in these substrates, ubiquitin ligases that ubiquitylate these substrates and inhibitors of the ubiquitylation of these substrates.
REFERENCES:
patent: 6165731 (2000-12-01), Deshaies et al.
patent: 6207369 (2001-03-01), Wohlstadter et al.
patent: 6413725 (2002-07-01), Deshaies et al.
patent: 6426205 (2002-07-01), Tyers et al.
patent: 2002/0025569 (2002-02-01), Caligiuri et al.
patent: 2003/0003460 (2003-01-01), Sigal et al.
patent: 2003/0113713 (2003-06-01), Glezer et al.
patent: 2003/0124572 (2003-07-01), Umek et al.
patent: 2003/0175679 (2003-09-01), Thomas et al.
patent: 2003/0207290 (2003-11-01), Kenten et al.
patent: 2004/0022677 (2004-02-01), Wohlstadter et al.
patent: 1182458 (2000-02-01), None
patent: WO 03/001889 (2003-01-01), None
patent: WO 03/022028 (2003-03-01), None
Elsasser, S. et al. Molecular Biology of the Cell vol. 10: 3263-3277 (1999).
Morishima-Kawashima, M. et al. Neuron 10(6): 1151-1160 (1993).
Pickart, C.M. Annu. Rev. Biochem. 70: 503-533 (2001).
Kleinschmidt, A. and Martinson, H. Nucleic Acid Research 9(11): 2423-2431 (1981).
Amano et al. “Thyroid hormone regulation of a transcriptional coactivator inXenopus laevis: Implication for a role in postembryonic tissue remodeling” Developmental Dynamics 223:526-535 (2002).
Artavanis-Tsakonas et al. “Notch signaling” Science 268:225-232 (1995).
Brenner “Hint, Fhit, and GaIT: Function, structure, evolution, and mechanim of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases” Biochemistry 41:9003-9014 (2002).
Brzovic et al. “The cancer-predisposing mutation C61G disrupts homodimer formation in the NH2-terminal BRCA1 RING finger domain” J. Biol. Chem. 273:7795-7799 (1998).
Bustin et al. “Expression of HMG chromosomal proteins during cell cycle and differentiation” Crit. Rev. Eukar. Gene Exp. 2:137-143 (1992).
Bustin et al. “High-mobility-group chromosomal proteins: Architectural components that facilitate chromatin function” Prog. Nucl. Acid Res. Mol. Biol. 54:35-100 (1996).
Clay-Farrace et al. “Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1” EMBO J. 22:704-712 (2003).
Coleman “The 3 Rs of Cdc6: Recruitment, regulation, and replication” Curr. Biol. 12:R759 (2002).
Compton et al. “The analysis of cThy28 expression in avian lymphocytes” Apoptosis 6:299-314 (2001).
Date et al. “Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene” Nature Genetics 29:184-188 (2001).
Davydov et al. “RGS4 is arginylated and degraded by the N-end rule pathway in vitro” J. Biol. Chem. 275:22931-22941 (2000).
De Groot et al. “Sindbis virus RNA polymerase is degraded by the N-end rule pathway” Proc. Natl. Acad. Sci. USA 88:8967-8971 (1991).
Delmolino et al. “Multiple mechanisms regulate subcellular localization of human CDC6” J. Biol. Chem. 276:26947-26954 (2001).
Ditzel et al. “Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis” Nature Cell Biol. 5:467-473 (2003).
Durocher et al. “The molecular basis of FHA domain: Phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms” Mol. Cell 6:1169-1182 (2000).
Ebneth et al. “Overexperssion of Tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria and endoplasmic reticulum: Implications for Alzheimer's disease” J. Cell Biol. 143:777-794 (1998).
Einck et al. “Inhibition of transcription in somatic cells by microinjection of antibodies to chromosomal proteins” Proc. Natl. Acad. Sci. USA 80:6735-6739 (1983).
Eng et al. “Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000)” Neurochem. Res. 25:1439-1451 (2000).
Gerdes et al. “Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation” Int. J. Cancer 31:13-20 (1983).
Goedert et al. “Multiple isoforms of human microtubule-associated protein Tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease” Neuron 3:519-526 (1989).
Golbe et al. “The Tau A0 allele in Parkinson's disease” Movement Disorders 16:442-447 (2001).
Guglielmi et al. “The yeast homolog of human PinX1 is involved in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibition” J. Biol. Chem. 277:35712-35719 (2002).
Han et al. “Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation” Nature 386:296-299 (1997).
Hateboer et al. “Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F” Mol. Cell. Biol. 18:6679-6697 (1998).
Hershko et al. “The ubiquitin system” Annu. Rev. Biochem. 67:425-479 (1998).
Hsieh et al. “CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex” Proc. Natl. Acad. Sci. USA 96:23-28 (1999).
Hwang et al. “A conserved RING finger protein required for histone H2B monoubiquitination and cell size control” Mol. Cell 11:261-266 (2003).
Ito et al. “Immunohistochemical localization of the nucleosome-binding protein HMGN3 in mouse brain” J. Histochem. & Cytochem. 50:1273-1275 (2002).
Jiang “Degrading Ci: Who is cul-pable?” Genes & Development 16:2315-2321 (2002).
Joazeiro et al. “The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase” Science 286:309-312 (1999).
Johnson et al. “Tau, where are we now?” J. Alzeimer's Dis. 4:375-398 (2002).
Kishi et al. “A critical role in Pin2/TRF1 in ATM-dependent regulation” J. Biol. Chem. 277:7420-7429 (2002).
Kishino et al. “UBE3A/E6-AP mutations cause Angelman syndrome” Nature Genetics 15:70-73 (1997).
Kosik et al. “Developmentally regulated expression of specific Tau sequences” Neuron 2:1389-1397 (1989).
Kuroda et al. “The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain” J. Biol. Chem. 277:9212-9218 (2002).
Kurz et al. “Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway” Science 295:1294-1298 (2002).
Kwon et al. “Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3α) of the N-end rule pathway” Mol. Cell. Biol. 21:8007-8021 (2001).
Kwon et al. “Bivalent inhibitor of the N-end rule pathway” J. Biol. Chem. 274:18135-18139 (1999).
Landsman et al. “Chromosomal protein HMG-17” J. Biol. Chem. 261:7479-7484 (1986).
Lecker et al. “Ubiquitin conjugation by the N-end rule pathway and mRNAs for its components increase in muscles of diabetic rats” J. Clin. Invest. 104:1411-1420 (1999).
Lee et al. “Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor” Mol. Endocrinol. 9:243-254 (1995).
Lu et al. “Competition for microtubule-binding with dual expression of Tau missense and splice isoforms” Mol. Biol. Cell 12:171-184 (2001).
Maeda et al. “In vitro ubiquitination of cyclin D1 and ROC1-CUL1 and ROC1-CUL3” FEBS Letters 494:181-185 (2001).
Mandelkow et al. “On the structure of microtubules, Tau, and paired helical filaments” Neurobiol. Aging 16:347-354 (1
Biebuyck Hans
Davydov Ilia
Kenten John H.
Oberoi Pankaj
Desai Anand U
Meso Scale Technologies LLC
Nixon & Vanderhye P.C.
LandOfFree
Substrates of N-end rule ubiquitylation and methods for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substrates of N-end rule ubiquitylation and methods for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substrates of N-end rule ubiquitylation and methods for... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4128010