Substrates having bound polysaccharides and bacterial nucleic ac

Details Substrates having bound polysaccharides and bacterial nucleic ac Substrates having bound polysaccharides and bacterial nucleic ac

1998-05-15

2000-07-11

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 23, 514 42, 514 43, 514 53, 514 54, 536 111, 536 221, 536 231, 5361231, A61K 3170, C08B 1100, C07H 2102

Patent

active

060873426

ABSTRACT:
The cytokine stimulating effects of immune- stimulating polysaccharides and bacterial nucleic acids, and of lower molecular weight fragments thereof, is potentiated by coupling the immune-stimulating bioactive substance to the surface of a substrate, which is preferably in particulate form.

REFERENCES:
patent: 5166137 (1992-11-01), Otterlei et al.
Espevik et al., "The involvement of CD14 in stimulation of cytokine production by uronic acid polymers", Eur. J. Immunol. 1993, 23:255-261.
Otterlei et al., "Similar Mechanisms of Action of Defined Polysaccharides and Lipopolysaccharides: Characterization of Binding and Tumor Necrosis Factor Alpha Induction", Infection And Immunity, May 1993, p. 1917-1925.
Ugelstad, et al., "Preparation And Application Of New Monosized Polymer Particles", Progress in Polymer Science, vol. 17, No. 1, pp. 87-161.
Rietschel et al., "Bacterial Endotoxin: Molecular Relationships Between Structure and Activity", Infectious Disease Clinics of North America, vol. 5, No. 4, Dec. 1991, pp. 753-779.
Hermanson et al. "Immobilized Affinity Ligand Techniques", Academic Press, Inc., 1992, pp. 80-85.
Seljelid et al., "The Protective Effect of .beta.1-3D-Glucan-Derivatized Plastic Beads against Escherichia coli Infection in Mice", Scand. J. Immunol. 25, 55-60, 1987.
Rasmussen et al., "Novel Immunomodulators With Pronounced In Vivo Effects Caused by Stimulation of Cytokine Release", Journal of Cellular Biochemistry 46:60-68 (1991).

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