Substrates for the quantitative assay of enzymes and such assay

Details Substrates for the quantitative assay of enzymes and such assay Substrates for the quantitative assay of enzymes and such assay

1980-12-01

1982-02-09

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

435 24, C07C10352, C12Q 136

Patent

active

043149367

ABSTRACT:
According to the present invention there are provided novel substrates for the determination of enzymes, and especially of the peptide hydrolases such as angiotensin-converting enzyme, trypsin and similar enzymes, and aminopeptidase-P, and to a process for the determination of these enzymes, which comprises contacting a biological fluid containing said enzyme with said substrate, which is cleaved, resulting in a pronounced fluorescence which is measured, thus giving a quantitative measure of the enzyme.

REFERENCES:
patent: 3884896 (1975-05-01), Blomback et al.
patent: 3886136 (1975-05-01), Claeson et al.
Chem. Abstr. 86, (1977) 39312d.
Chem. Abstr. 72, (1970) 51996y.

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