Substrates, compositions, elements and methods for the determina

Details Substrates, compositions, elements and methods for the determina Substrates, compositions, elements and methods for the determina

1985-09-26

1988-06-14

Warden, Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

435 16, 435 24, 435805, 546141, 546142, 546143, 546153, 546155, 546159, C12Q 148

Patent

active

047511788

ABSTRACT:
New substrates for .gamma.-glutamyltransferase (.gamma.-GT) are disclosed. These subtrates are useful in the colorimetric determination of .gamma.-GT since the cleavage of the .gamma.-glutamyl group produces a detectable species--an aminostyrylquinolinium dye. The substrates have the formula: ##STR1## wherein: R and R.sub.1 are independently selected from hydrogen, alkyl and alkoxy and

REFERENCES:
patent: 3703441 (1972-11-01), Nakanishi et al.
patent: 3979447 (1976-09-01), Bernt et al.
patent: 4087331 (1978-05-01), Bucolo
patent: 4167449 (1979-09-01), Gargiulo
patent: 4177109 (1979-12-01), Tohyama et al.
patent: 4560650 (1985-12-01), Bauer, III
patent: 4567138 (1986-01-01), Beck
patent: 4603107 (1986-07-01), Deneke

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