Substrate trapping protein tyrosine phosphatases

Details Substrate trapping protein tyrosine phosphatases Substrate trapping protein tyrosine phosphatases

1996-07-25

1999-06-15

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435196, C12N 916, C12Q 142

Patent

active

059121386

ABSTRACT:
Novel protein tyrosine phosphatases in which the invariant aspartate residue is replaced with an alanine residue and which bind to a tyrosine phosphorylated substrate and are catalytically attenuated are described. Also described are methods of identifying tyrosine phosphorylated proteins which complex with the described protein tyrosine phosphatases.

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