Substrate-related peptidyl-aldehyde inhibitors of the proteolyti

Details Substrate-related peptidyl-aldehyde inhibitors of the proteolyti Substrate-related peptidyl-aldehyde inhibitors of the proteolyti

1994-03-04

1996-12-03

Woodward, Michael P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530330, A61K 3804

Patent

active

055808549

ABSTRACT:
The present invention provides novel peptidylaldehyde inhibitors of proteolysis mediated by the multicatalytic proteinase complex (MPC) or proteasome. The inhibitors have the general formula

REFERENCES:
Orlowski, M., Biochemistry 29:10289-10297 (1990).
Ruddinger, J. in "Peptide Hormones", J. A. Parsons, Ed., University Park ss, Baltimore (1976), pp. 1-7, see p. 4 lines 4 ff.
Orlowski, M., J. Lab. & Clin. Med. 121:187-189 (1993).
Tanaka et al., J. Cell. Physiol. 139:34-41 (1989).
Amsterdam et al., Proc. Natl. Acad. Sci. USA 90:99-103 (1993).
Dahlmann et al., FEBS Lett. 251:125-131 (1989).
Eytan et al., Proc. Natl. Acad. Sci. USA 86:7751-7755 (1989).
Rechsteiner et al., J. Biol. Chem. 268:6065-6068 (1993).
Glotzer et al., Nature (London) 349:132-138 (1991).
Ciechanover et al., Proc. Natl. Acad. Sci. USA 88:139-143 (1991).
Murakami et al., Nature (London) 360:597-599 (1992).
Fujiwara et al., J. Biol. Chem. 265:16604-16613 (1990).
Beyon, Intl. Committee on Proteolysis Newsletter, Jan., 1-2 (1994).
Brown et al., Nature (London) 353:355-360 (1991).
Goldberg et al., Nature (London) 357:375-379 (1992).
Wilk and Orlowski, J. Neurochem. 35:1172-1182 (1980).
Wilk and Orlowski, J. Neurochem. 40:842-849 (1983).
Orlowski and Wilk, Biochem. Biophys. Res. Comm. 101:814-822 (1981).
Orlowski et al., Biochemistry 28:9270-9278 (1989).
Orlowski et al., Biochemistry 32:1563-1572 (1993).
Schecter and Berger, Biochem. Biophys. Res. Commun. 27:157-162 (1967).
Cardozo et al., Biochemistry 31:7373-7380 (1992).
Anderson et al., J. Am. Chem. Soc. 86:1839-1842 (1963).
Vinitsky et al., Biochemistry 31:9421-9428 (1992).
Orlowski & Michaud, Biochemistry 28:9270-9277 (1989).
Pfitzner and Moffat, J. Am. Chem. Soc. 87:5661-5670 (1965).
Reingold & Orlowski, J. Neurochem. 32:907-913 (1978).
Goldbarg & Rutenberg, Cancer 11:283-291 (1958).
Bratton & Marshall, J. Biol. Chem. 128:537-550 (1939).
Pfleiderer, Meth. Enzymol. 19:514.varies.521 (1970).
Almenoff & Orlowski, Biochemistry 22:590-599 (1983).
Dixon, Biochem. J. 55:170-171 (1953).
Orlowski et al., Biochemistry 30:5999-6005 (1991).

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