Substrate for phospholipase

Details Substrate for phospholipase Substrate for phospholipase

1989-03-02

1992-02-25

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

548414, 548484, 549 5, 549 7, 549 11, 549 33, 558180, 558169, 558 32, C07D26538, C07C30510, C07F 910

Patent

active

050915274

ABSTRACT:
The present invention provides phospholipase substrates of the general formula: ##STR1## wherein A is an alkylene or alkenylene radical containing up to 16 carbon atoms, R is a hydrgen atom or an alkyl, alkenyl or acyl radical containing up to 20 carbon atoms or an optionally alkyl-substituted aryl or aralkyl radical containing up to 8 carbon atoms in the alkyl moiety, X is the residue of an aromatic hydroxy or thiol compound and each Y, independently of one another, is an oxygen or sulphur atom and Z is --SO.sub.3.sup..crclbar. or a radical of the general formula: ##STR2## wherein R.sup.1 can be a hydrogen atom or a radical of the general formula --(CH.sub.2).sub.n NR.sub.3.sup.2, in which n is 2, 3 or 4 and R.sup.2 is a hydrogen atom or a methyl radical, or is an inositol or serine (--CH.sub.2 --CH(NH.sub.2)--COOH) or glycerol residue.
The present invention also provides a process for the optical determination of phospholipases using these substrates, as well as a reagent containing them.

REFERENCES:
patent: 4485045 (1984-11-01), Regen
patent: 4847376 (1989-07-01), Neumann et al.
Kodama et al, Chem. Abstracts, vol. 108 (1988) p. 22209a.
Synthesis-Journal of Synthetic Organic Chemistry, Jan. (1987), No. 1, New York, NY, pp. 60-62.

Affiliated with

Also associated with

Rating

Substrate for phospholipase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substrate for phospholipase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substrate for phospholipase will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1894133