Substrate for controlling growth direction of nerve fibers and p

Details Substrate for controlling growth direction of nerve fibers and p Substrate for controlling growth direction of nerve fibers and p

1991-06-10

1999-04-27

Lankford, Jr., Leon B.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Solid support and method of culturing cells on said solid...

435402, C12N 500

Patent

active

058980008

ABSTRACT:
A substrate for controlling the growth direction of serve fibers charcterized in that a nerve cell adhesive substance is fixed in the form of a desired pattern and a process for preparing the substrate, a method for controlling the growth direction of nerve fibers and a neuronal network.
According to this invention, precise control of nerve fibers' growth direction is achieved.

REFERENCES:
patent: 4554237 (1985-11-01), Kataoka et al.
patent: 4560640 (1985-12-01), Ichihashi et al.
patent: 4775730 (1988-10-01), Gupta
patent: 4797348 (1989-01-01), Nakamura et al.
patent: 4830953 (1989-05-01), Bateman
patent: 4996123 (1991-02-01), Nomura et al.
The Journal of Neuroscience, "Controlled Outgrowth of Dissociated Neurons on Patterned Substrates", by D. Kleinfeld, K.H. Kahler, and P.E.Hockberger Nov. 1988, 8 (11), pp. 4098-4120.
Experimental Cell Research 179, "Cytoscribing: A Method for Micropositioning Cells and the Construction of Two-and Three-Dimensional Synthetic Tissues", by Robert J. Klebe, 1988, pp. 362-373.
Experimental Cell Research 77, "Behavior of Cultured Cells on Substrata of Variable Adhesiveness", by Albert Harris, 1973, pp. 285-297.
Brain Research, 446, "Recognition of artificial microstructures by sensory nerve fibers in culture", by Takushi Hirono, Keiichi Torimitsu, Akio Kawana and Jun Fukuda, 1988, pp. 189-194.

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