Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1991-01-11
1992-03-03
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 71, 435 79, 435 792, 435174, 435975, C12Q 170, C12Q 100, G01N 3353, C12N 1100
Patent
active
050932314
ABSTRACT:
A composition contains levamisole and a substrate for alkaline phosphatase in a high pH buffer including 2-amino-2-methyl-1-propanol. The composition may be included in a kit of materials useful in performing an immunoassay in which intestinal alkaline phosphatase is the label. The invention includes a method for detection of a viral antigen by an immunoassay including intestinal alkaline phosphatase as the label and the composition of the invention to provide stabilized levamisole to inhibit nonintestinal alkaline phosphatase.
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Morris, J. of Immunological Methods, 68 (1984) 11-17.
Tumosa et al., J. of Immunological Methods, 116 (1989) 59-63.
Ponder BA et al., Biological Abstracts, Inhibition of Endogenous Tissue Alkaline Phosphatase EC-3.1.31 with the use of Alkaline Phosphatase Conjugates in Immuno Histochemistry (1981) Biosis No. 73032984.
Becton Dickinson and Company
Brown Richard E.
Robinson Douglas W.
Weber Susan M.
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