Substrate assisted catalysis

Details Substrate assisted catalysis Substrate assisted catalysis

1993-07-12

1994-12-06

Patterson, Jr., Charles L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435222, 435221, C07K 1500, C12N 956

Patent

active

053711904

ABSTRACT:
Novel enzyme mutants are disclosed which are derived from a precursor enzyme by replacing or modifying at least one catalytic functional group of an amino acid residue in a precursor enzyme. Such mutant enzymes have a catalytic preference for substrates which provide the replaced or modified catalytic group or its equivalent such that the substrate together with the enzyme mutant assists in its own catalysis.

REFERENCES:
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patent: 4760025 (1988-07-01), Estell et al.
Estell, P. A., et. al. (1986) Science 233, 659-663.
Wells, J. A., et. al. (1987) Proc. Natl. Acad. Sci, U.S.A, 84, 1219-1223.
Wells, J. A. et al. (1987) Proc. Natl. Acad. Sci, U.S.A. 84, 5167-5171.
Grant et al. (1987) in: Grant & Hackh's Chemical Dictionary, p. 214.
Wells, J. A., et. al. (1987) Cold Spring Harbor Symp. Quant. Biol 52 647-652.
Uasantha, N., et. al. (1986) J. Bacteriol. 165(3), 837-847.
Carter, P., et. al. (1987) Science 237, 394-399.
Zaghloul T. I, et. al, (1985) J. Bacteriol. 164(2), 550-555.

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