Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is inorganic
Patent
1995-05-30
1996-06-18
Housel, James C.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is inorganic
427287, 4273831, 427404, 427414, 422 57, 422 58, 436518, 436527, 436531, 436532, 436534, 436805, G01N 33553
Patent
active
055277128
ABSTRACT:
A substrate for surface-enhanced analytical procedures, such substrates prepared for use in specific procedures to detect specific binding partner molecules, and a method for making them. The substrate is a body having a substrate surface on which there are randomly spaced apart metal islands. A continuous layer of coupling agent coats the islands and any intervening substrate surface. First binding partner molecules are bonded to the coupling agent. These are specifically attractive to specified second partner molecules for an analytical procedure for detecting the presence of, and perhaps the concentration of second partner molecules, or in some procedures, of a specified third binding partner molecule which becomes bonded to the second binding partner molecule. The thickness of the coupling agent layer is selected to improve the sensitivity of a given analytical procedure for detecting or measuring the specific binding partner molecule.
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Chin Christopher L.
Housel James C.
Medifor Limited, an Irish Corporation
Sherman Kenneth L.
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