Substitution analogues of magainin peptides

Details Substitution analogues of magainin peptides Substitution analogues of magainin peptides

1994-11-14

1999-06-15

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 14, 514 15, 530326, 530327, A61K 3810, A61K 3816, C07K 708, C07K 1400

Patent

active

059122315

ABSTRACT:
A compound comprising a Magainin I or Magainin II peptide wherein at least one substitution may be made for certain amino acid residues with other amino acid residues, said peptides known as substitution analogues.
In addition to such substitutions, there can be included within the scope of the invention analogues wherein at least one of amino acid residues 15 and 23 may have been deleted as well, and wherein substitutions were made in the remaining peptide chain. Certain substituttion analogues within the scope of the present invention have been shown to possess increased biological activity.

REFERENCES:
patent: 4810777 (1989-03-01), Zasloft
patent: 4962277 (1990-10-01), Cuervo et al.
patent: 5045531 (1991-09-01), Berkowitz et al.
patent: 5208220 (1993-05-01), Berkowitz
patent: 5217956 (1993-06-01), Zasloff et al.
patent: 5221664 (1993-06-01), Berkowitz et al.
patent: 5221732 (1993-06-01), Chen et al.
patent: 5235038 (1993-08-01), Blondelle et al.
Chen et al. `Magainnin 2 Amide And Analogues` Febs Letters, vol. 249, No. 2, pp. 219-223, Jun. 1989.
Cuervo et al. `The Magainis: Sequence Factors Relavant To Increased Antimicrobial Activity And Decreased Hemolytic Activity` Peptide Research, vol. 1, No. 2 pp. 81-86, 1988.
Spatol, AF. Chemistry And Biochemistry Of Amino Acids, Peptides And Proteins. New York: Marcel Dekker, Inc., ppl 284-285, 1983.
Chen, et al, vol. 236, No. 2, pp. 462-466, FEB, 1988.
Cuervo, et al, vol. 1, No. 2, Peptide Research, 1988.
Christensen, et al, vol. 85, Proc. Natl. Acad. Sci, pp. 5072-5076).
Zasloff et al., Proc. Natl. Acad. Sci., USA, 85:910-913 (1988).
Chen et al., FEB, 236(2):462-466 (Aug. 1988).
Cuervo et al., Peptide Research, 1(2):81-86 (Nov.-Dec. 1988).
Cuervo et al., Peptides, Chemistry, Structure and Biology, Proceedings of the Eleventh American Peptide Symposium, Jul. 9-14, 1989, La Jolla, California, U.S.A.; Rivier and Marshall eds., ESCOM, Leiden (1990), pp. 124-126. Centre) May 26, 1988; Abstract.
Tjoeng et al., Int. J. Peptide Protein Res., 35:141-146 (1990).
Chen et al, vol. 236, No. 2, 462-466, 1988.
Cuervo, et al, Peptides, pp. 124-126, 1990.

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