Substituted γ-lactone compounds as NMDA-antagonists

Details Substituted γ-lactone compounds as NMDA-antagonists Substituted γ-lactone compounds as NMDA-antagonists

2005-10-18

2005-10-18

Dentz, Bernard (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S255050, C514S275000, C514S313000, C514S336000, C514S407000, C544S332000, C544S336000, C546S159000, C546S284400, C548S371400, C549S303000, C549S321000

Reexamination Certificate

active

06956055

ABSTRACT:
The invention relates to substituted γ-lactone compounds, to methods for the production thereof, to medicaments containing these compounds and to the use of these compounds for producing medicaments.

REFERENCES:
patent: 0386839 (1997-01-01), None
patent: WO 97/12879 (1997-04-01), None
patent: WO 98/07704 (1998-02-01), None
patent: WO 98/42673 (1998-10-01), None
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“A New Synthesis Of Amino Acids. II. Amidoalkylation of Olefins With Glyoxylic Acid Derivatives”, Ben-Ishai et al., Tetrahedron Lett. 1975, vol. 33, pp. 1533-1442.
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“[3H]MDL 105,519, a High-Affinity Radioligand for the N-Methyl-D-aspartate Receptor-Associated Glycine Recognition Site”, Baron et al., Jnl of Pharm. And Experimental Therapeutics, 1996, pp. 62-68.

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