Substituted vinylurea derivatives and medicine containing the sa

Details Substituted vinylurea derivatives and medicine containing the sa Substituted vinylurea derivatives and medicine containing the sa

1997-07-24

1999-02-02

Kumar, Shailendra

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514255, 514329, 514464, 514535, 514564, 514595, 514598, 514524, 544386, 544390, 544391, 546224, 549434, 549435, 560 34, 562439, 564 48, 564 52, 558417, A61K 3117, C07C27528, C07C27504

Patent

active

058666095

ABSTRACT:
Disclosed herein are substituted vinylurea derivatives represented by the following general formula (1): ##STR1## wherein R.sup.1 and R.sup.3 are independently a phenyl group which may be substituted, R.sup.2 is a phenyl group which may be substituted, or a cycloalkyl group, and wave lines mean that the bonding state may be either E or Z, with the proviso that the cases where R.sup.1, R.sup.2 and R.sup.3 are unsubstituted phenyl groups, and where R.sup.1 and R.sup.2 are unsubstituted phenyl groups and R.sup.3 is a 4-ethoxyphenyl group are excluded, or salt thereof, and medicines comprising such a derivative as an active ingredient as well as a method of preventing and treating arteriosclerosis with such a medicine. The derivatives or salts thereof selectively and strongly inhibit ACAT in macrophages and are hence useful as prophylactic and therapeutic agents for arteriosclerosis.

REFERENCES:
Eiden et al, Arch. Pharm, No. 7, pp. 445-455, 1963.
Tawada et al, J.Med.Chem., vol. 37, pp. 1067-1083, 1994.
Maduskuie et al, J. Med. Chem, vol. 38, pp. 1067-1083, 1995.

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