Substituted tryptamines, phenalkylamines and related compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514361, 514381, 514414, 514415, 514419, 548125, 548143, 548144, 548250, 548252, 548253, 548254, 548455, 548457, 548458, 548465, 548483, 548492, 548493, 548494, 548504, 548506, 548507, A61K 3142, A61K 3141, C07D27110, C07D20908

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active

054038510

ABSTRACT:
This invention relates to novel substituted tryptamine and phenalkylamine and related compounds, pharmaceutical compositions thereof and methods of using said compounds and compositions for a number of pharmaceutical indications including (but not limited to): 1. central nervous system and psychiatric disorders (e.g., sleep disorders, epilepsy and other convulsive disorders, anxiety, psychiatric diseases, neurodegenerative diseases, fever); 2. chronobiological-based disorders (e.g., jet lag, delayed sleep syndrome, shift-work, seasonal affective disorder); 3. endocrine indications (e.g., contraception and infertility, precocious puberty, premenstrual syndrome, hyperprolactinemia, growth hormone deficiency); 4. cancer and other proliferative diseases; 5. immune system disorders and conditions associated with senescence; 6. ophthalmological diseases; 7. animal breeding (e.g., regulation of fertility, puberty, pelage color).

REFERENCES:
CA112:235837y Derivatives . . . antagonists Kerwin et al. p. 677, 1990.

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