Substituted tricyclic compounds as protein kinase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C544S250000

Reexamination Certificate

active

11092168

ABSTRACT:
Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure:including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from:and wherein R1, R2, R3, X, Z, L1, Cycl1, L2and Cycl2are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

REFERENCES:
patent: 0 837 063 (1998-04-01), None
patent: WO 96/09294 (1996-03-01), None
patent: WO 96/33981 (1996-10-01), None
patent: WO 01/21596 (2001-03-01), None

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