Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-01-28
1993-10-05
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514384, 514315, 514336, 514343, 514461, 514465, 514408, 514427, 514329, 514330, A61K 3141, A61K 3134, A61K 3140, A61K 31445
Patent
active
052505588
ABSTRACT:
Substituted triazolinone, triazolinethione, and triazolinimine compounds of formula (I) are as neurotensin II antagonists. These compounds have the general formula: ##STR1##
REFERENCES:
patent: 4425269 (1984-01-01), Christy et al.
patent: 4439359 (1984-03-01), Holly et al.
patent: 5100910 (1992-03-01), Milcent et al.
patent: 5137902 (1992-08-01), Carini
patent: 5137906 (1992-08-01), Chiu et al.
"Sanofi presents novel products", Scrip World Pharmaceutical News, Dec. 4, 1992, No. 1776.
deQuidt et al, "Neutrotensin facilitates dopamine release in vitro from rat striatal slices", Brain Research, 274, (1983), 376-380.
Shi et al, "Roles of Intracellular cAMP and Protein Kinase A in the Actions of Dopamine . . . ", J. of Neuroscience, Jun. 1992, 12(6): 2433-2438.
Szigethy et al, "Correspondence Between High Affinity 125 I-Neurotensin Binding Sites . . . ", J. of Comp. Neurology 279: 128-137 (1989).
Kitabgi, "Neurotensin Modulates Dopamine Neurotransmission at Several Levels . . . ", Neurochem Int., vol. 14, No. 2, pp. 111-119 (1989).
Blaha et al, "Effects of Neurotensin on Dopamine Release and Metabilish in the Rat Striatum . . . ", Neuroscience, vol. 34, No. 3, pp. 699-705 (1990).
Palacios et al, "Neurotensin receptors are located on dopamine-containing neurones in rat midbrain", Nature, vol. 294, Dec. 10, 1981, pp. 587-589.
Glimcher et al, "Neurotensin self-injection in the ventral tegmental area", Strain Research, 403, (1987), pp. 147-150.
Stoessl et al, "Neurotensin and neurotensin analogues modify the effect of chronic neuroleptic . . . ", Strain Research, 558, (1991), pp. 289-295.
Rompre et al, "Faciliration of brain stimulation reward by mesencephalic injections . . . ", European J. of Pharm., 211 (1992), pp. 295-303.
Prange et al, "The Manifold Actions of Neurotensin: A First Synthesis", NYAS, pp. 368-375, (1982).
G. A. Cain, et al. Neurotensin Based Analgesics: 203rd National Meeting of the Am. Chem. Soc. Apr. 5-10, (1992).
Chakravarty Prasun K.
Ransom Richard W.
Camara Valerie J.
Criares T. I.
DiPrima Joseph F.
Merck & Co. , Inc.
Nicholson William H.
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