Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2004-11-10
2008-12-02
Shiao, Rei-tsang (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S262200
Reexamination Certificate
active
07459475
ABSTRACT:
Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.
REFERENCES:
patent: 2005/0119261 (2005-06-01), Chakravarty et al.
patent: 2006/0183897 (2006-08-01), Chakravarty et al.
patent: WO 01/68612 (2001-09-01), None
patent: WO 01/72714 (2001-10-01), None
patent: WO 03/022276 (2003-03-01), None
patent: WO 2004/083189 (2004-09-01), None
patent: WO 2004/083190 (2004-09-01), None
Copending U.S. Appl. No. 10/549,790 and U.S. Appl. No. 10/799,230.
Misbahul Ain Khan, et al.,Synthesis of Heterocyclic Compounds, 3 (3), pp. 119-121 (1972).
Chakravarty Prasun K.
Gonzalez Edward
Ok Hyun
Palucki Brenda
Park Min K.
Ayler Sylvia A.
Chung Susannah
Krovatin William
Merck & Co. , Inc.
Shiao Rei-tsang
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