Substituted triazole derivatives as oxytocin antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C544S336000, C546S348000, C548S266200

Reexamination Certificate

active

07618972

ABSTRACT:
The present invention relates to a class of substituted triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.).

REFERENCES:
patent: 2503059 (1950-04-01), Miescher et al.
patent: 2599000 (1952-06-01), Kerwin et al.
patent: 3381009 (1968-04-01), Palazzo et al.
patent: 3511836 (1970-05-01), Hans-Jurgen et al.
patent: 3527761 (1970-09-01), Archibald et al.
patent: 3997666 (1976-12-01), Witte et al.
patent: 4026894 (1977-05-01), Winn et al.
patent: 4188390 (1980-02-01), Campbell
patent: 4252721 (1981-02-01), Silvestrini et al.
patent: 4315007 (1982-02-01), Manoury
patent: 4703063 (1987-10-01), Imai et al.
patent: 5698560 (1997-12-01), Onoda et al.
patent: 5801180 (1998-09-01), Takase et al.
patent: 5861396 (1999-01-01), Niewohner et al.
patent: 5945117 (1999-08-01), El-Rashidy et al.
patent: 0526004 (1997-10-01), None
patent: 0995750 (1999-10-01), None
patent: 1092718 (2000-10-01), None
patent: 1092719 (2000-10-01), None
patent: 1097719 (2000-11-01), None
patent: 1293503 (2001-05-01), None
patent: WO9111172 (1991-08-01), None
patent: WO9312095 (1993-06-01), None
patent: WO9400453 (1994-01-01), None
patent: WO9492518 (1994-02-01), None
patent: WO9405661 (1994-03-01), None
patent: WO9415932 (1994-07-01), None
patent: WO9849166 (1998-11-01), None
patent: WO9902159 (1999-01-01), None
patent: WO9904433 (1999-01-01), None
patent: WO9954333 (1999-10-01), None
patent: WO0002550 (2000-01-01), None
patent: WO0024745 (2000-05-01), None
patent: WO0028993 (2000-05-01), None
patent: WO0035298 (2000-06-01), None
patent: WO0127112 (2001-04-01), None
patent: WO0127113 (2001-04-01), None
patent: WO0158880 (2001-08-01), None
patent: WO 2005/028452 (2005-03-01), None
Jordan, V. C. Nature Reviews: Drug Discovery, 2, 2003, p. 205.
Chawla, et al. Curr. Res. & Info. Pharm. Sci. (CRIPS), 5, 1, 2004, pp. 9-12.
Patani, et al. Chem. Rev., 96, 1996, pp. 3147-3176.
Arletti, et al.,Peptides, “Influence of oxytocin on feeding behavior in the rat.”, 10(1), 89-93, (1989).
Berman, et al.,Urology“Female sexual dysfunction: incidence, pathophysiology, evaluation, and treatment options”, vol. 54(3), 385-91, (1999).
Finnin, et al.,Journal Pharm Science, ‘Transdermal Penetration Enhancers : Applications, Limitations, and potential’, vol. 88 (10), 955-958, (1999).
Gimpl, et al.,Physiological Reviews, “The oxytocin receptor system: structure, function, and regulation.” vol. 81(2), 629-683, (2001).
Leiblum S R,International Journal of Impotence Research, “Definition and classification of female sexual disorders” (1998), 10 Suppl 2 S104-6.
Liang, et al.,Expert Opinion in Therapeutic Patents, “Fast-dissolving intraoral drug deliver system”, vol. 11 (6), 981-986, (2001).
Melman, et al.,The Journal of Urology, “The epidemiology and pathophysiology of erectile dysfunction.” vol. 161(1), 5-11, (1999).
Nicholson, et al,Advances in Experimental Medicine and Biology, “Oxytocin and prostatic function.” vol. 395(Oxytocin), 529-538, (1995).
Rotella, et al.,Journal of Medicinal Chemistry, “N-3-Substituted Imidazoquinazolinones: Potent and Selective PDE5 Inhibitors as Potential Agents for Treatment of Erectile Dysfunction.” vol. 43(7), 1257-1263, (2000).
Truitt, et al..Science. “Identification of a potential ejaculation generator in the spinal cord.” vol. 297, 1566-1569, (2002).
Verma et al.,Pharmaceutical Technology On-line, Drug delivery technologies and future directions, vol. 25(2), 1-14,(2001).

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