Substituted triazines as prion protein ligands and their use...

Details Substituted triazines as prion protein ligands and their use... Substituted triazines as prion protein ligands and their use...

2005-07-25

2011-10-04

Balasubramanian, Venkataraman (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C544S196000, C544S204000, C544S219000, C514S241000, C514S245000

Reexamination Certificate

active

08030484

ABSTRACT:
Compounds of formula (I) wherein R1and R2are the same or different and are each optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl groups; R3is hydrogen or an aryl group substituent or R3is a solid support optionally attached via a spacer; Z represents an oxygen atom, a sulphur atom or NR4; Y represents an oxygen atom, a sulphur atom or NR5; in which R4and R5, which may be the same or different, represent hydrogen, optionally substituted alkyl containing 1 to 6 carbon atoms, optionally substituted phenyl, optionally substituted benzyl or optionally substituted β-phenylethyl; and one of X1and X2represents a nitrogen atom and the other of X1and X2represents a nitrogen atom or CR6, in which R6represents hydrogen or an aryl group substituent; are useful for the affinity binding of a prion protein.

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